Magnesium

Health – Aging and the Brain

by

Several studies have shown a link between the number of infections throughout a person’s life and later development of neurodegenerative diseases such as Alzheimer’s disease.

As we age, our immune systems become less efficient in combating infections. This is mainly due to poor nutrition and can be corrected simply by improvements in diet.

Nutrients That Prevent Alzheimer’s

Resveratrol, one of the active components of grapes, has been shown to reduce the accumulation of a substance called amyloid beta in the brain, and to suppress inflammation of the brain by inhibiting microglial activation—which is the mechanism for amyloid production. (Ono, K., et. al., J Neurosci 2004; 75: 742-750; Bi, X.L., et. al., Int Immunopharmacology 2005; 5: 185-193.)

Amyloid is the brain “crud” that accumulates in the brains of people who suffer from Alzheimer’s disease. Another beneficial plant flavonoid is called baicalein, an extract of a plant called skullcap, which has been shown to protect brain cells from damage by toxins and excitotoxicity (the process of nerve damage through continuous stimulation), as well as safeguarding the brain during strokes. Skullcap powerfully protects against free radical creation and lipid peroxidation in the brain, and reduces microglia-induced brain inflammation and immunoexcitotoxicity (excitotoxicity triggered by the body’s immune response). (Uchida, K., et. al., J Biol Chem 1999; 2234-2342; Kobuchi, H., et. al., Am J Physiol 1999; 277: C403-411.) A number of plant flavonoids also chelate iron, which means they bind the iron atoms, preventing the formation of free radicals, and thus protecting the brain. Flavonoids with this property include:

  • Curcumin
  • Green and white tea flavonoids
  • Quercetin
  • Hesperidin
  • Luteolin
  • Baicalein

This is important property because free iron in specific locations in the aging brain is associated with neurodegenerative diseases, especially Parkinson’s and Alzheimer’s disease, and plays a major role in stroke damage. These flavonoids do not interfere with normal iron functions. Luteolin, found in high concentrations in celery and parsley not only reduces microglial activation, it also switches microglia to a protective state, a mechanism that is impaired with Alzheimer’s disease and possibly chronic brain damage associated with multiple brain injuries in sports (chronic traumatic encephalopathy). (Blaylock, R. and Maroon, J., Sur Neurol Int 2011.)

Another study found that both apigenin (another flavonoid) and luteolin protect the brain by reducing microglial activation. (Resai-Zadeh, K., et. al., J Neuroinflammation 2008; 5: 41.) In addition, there is strong evidence that activation of microglia in the aging brain is playing a central role in a number of neurological disorders, including strokes, brain infections, vaccine damage, brain trauma, and neurodegenerative diseases. (Dilger, R.N., et. al., J Leukoc Biol 2008; 84; 932-939.)

As we age, the microglia in the brain become progressively more activated. In people with Alzheimer’s dementia, there is widespread, intense microglial activation. A number of flavonoids control brain inflammation by suppressing microglial activation; these include curcumin, quercetin, fisetin, EGCG, and resveratrol.

Excitotoxicity and Magnesium Levels

As we grow older the brain becomes progressively more inflamed. With age-related memory loss and Alzheimer’s dementia, the degree of inflammation increases dramatically.

Brain inflammation is caused by microglial activation; these immune cells are also the source of glutamate and other excitotoxins. Magnesium, which is abundant in fruits, vegetables, and nuts, suppresses excitotoxicity and inflammation.

Meanwhile, because of their high level of phosphoric acid, soft drinks deplete magnesium and play a major role in the widespread magnesium deficiency seen in the Western world.

Many prescription medications and birth control pills on the market also severely deplete magnesium.

Studies conducted by Dr. Mark Mattson and his co-workers have shown that physical exercise stimulates brain cells to release higher levels of growth factors (neurotrophins), which protect the brain from damage, heal existing injuries, prevent depression, and promote better memory and learning capacity. (Boyle, P.A., et. al., Arch Gen Psychiatry 2010; 67: 304-310.)

Mattson has also studied the effect of caloric restriction on brain protection, and demonstrated that reducing one’s intake of calories significantly reduces brain aging and stimulates the release of neurotrophic brain growth factors.

Caloric restriction also increases antioxidant enzyme levels and reduces excitotoxicity. (Mattson, M.P. and Ann, N.Y., Acad Sci 2008; 1144: 97-112.)

Of course, many people find it difficult to reduce their caloric intake enough to obtain these beneficial effects. However, new studies have shown that fasting just one day a week has the same beneficial effect; adding resveratrol to the diet has also been shown to be effective.

Recent studies have shown that daily physical exercise also increases a person’s thinking ability and reduces the risk of early onset dementia. (Wang, L., et. al., Arch Inter Med 2006; 166: 115-1120.)

Moderate exercise—such as brisk walking, using light weights or exercise machines—is sufficient for the elderly. Engagement in social events, reading, learning new topics, and participating in church functions are also important.

If we exercise regularly, fast once a week, and engage in regular intellectual activities, the benefits for brain health will be significant. Adding good nutrition—including eating a variety of flavonoids—will tremendously magnify those health benefits.

Source: Blaylock Wellness Report, November 2011.

Health – Magnesium – Why You Need It

by

Researchers have found magnesium to be a vital mineral that can lower blood pressure, protects the heart, and prevents stroke.

It has been shown to boost everything from heart health to bone density, and it can lower the risk of diabetes, high blood pressure, and stroke. It even improves memory, eases anxiety, treats headaches, and targets depression.

Magnesium is an inexpensive, readily available essential nutrient that many health experts are calling a “miracle mineral.”

But chances are that you, like most people, don’t get enough of it. Carolyn Dean, M.D., author of The Magnesium Miracle tells Newsmax that it is the most beneficial health-boosting mineral available. Yet most people have never heard of it … .

“Magnesium affects every organ, tissue, and cell in the body,” said Dean, a Hawaii-based physician and holistic specialist. “Magnesium deficiency is killing people, and it’s a simple solution to many of our chronic diseases.” Government studies going back more than two decades have found the standard American diet fails to meet the U.S. Food and Drug Administration’s recommended daily allowance of magnesium, which is 400–420 mg per day for men, and 310–320 for women. Dean believes health officials and the mainstream medical establishment need to do more to raise the public awareness of magnesium’s many benefits.

“A hundred years ago we were getting 500 mg in our daily diet,” she said. “Today we are fortunate to get 200 mg. Most people think that their doctors would have warned them about this problem. But doctors are as ignorant as the public about magnesium’s health effects.”

Nature’s Disease Fighter

Magnesium is one of the body’s most common essential minerals. It is found in the body’s muscles, bones, blood, and tissues. It is involved in regulating everything from blood pressure to heart activity, energy production, nervous system function, cell growth, bone density, muscle strength, and metabolism.

Magnesium is present in a range of foods, including spinach, wheat germ, bran cereals, brown rice, beans, tofu, soybeans, and nuts. But the problem is that decades of commercial agricultural processes have depleted the levels of magnesium and other nutrients in farm soils. This has resulted in less of the nutrients being in fruits and vegetables.

A U.S. Department of Agriculture study published in the Journal of the American College of Nutrition found the levels of nutrients in American-grown produce were as much as 38 percent higher in 1950 than they are today. A growing body of scientific evidence has shown that magnesium deficiency can raise the risk of a range of diseases.

Blood pressure: Over a four-year period, men with sufficient magnesium had a lower risk of hypertension than men consuming lower levels, according to a study of 30,000 men. A second survey of 8,000 women also found that the risk of hypertension decreased as dietary magnesium intake increased.

Heart disease, stroke: Magnesium helps regulate heart rate, says Chauncey Crandall, M.D., director of preventive medicine at the Palm Beach Cardiovascular Clinic. “The mineral is particularly important for people who have had an irregular heartbeat,” he told Newsmax. “Magnesium helps suppress extra heartbeats.”

A 2011 study published in the American Journal of Clinical Nutrition found a 40 percent greater risk of sudden cardiac death among women with low levels of magnesium.

Several other studies have linked higher blood levels of magnesium to a lower risk of heart disease and stroke.

Diabetes: Magnesium is a key regulator of carbohydrate metabolism. It influences the release and activity of insulin, the hormone that helps control blood sugar levels. Low blood levels of magnesium are often seen in Type 2 diabetes patients.

Two major research projects, the “Nurses’ Health Study” and the “Health Professionals’ Follow-Up Study,” that followed more than 170,000 people, have found the risk for Type 2 diabetes is greater in people with lower magnesium.

Osteoporosis: Calcium and vitamin D are important for bone health. But studies also show magnesium deficiency is a risk factor for postmenopausal osteoporosis. This is probably because magnesium deficiency alters calcium metabolism and the hormones that regulate calcium absorption. Several studies have found that magnesium supplements and diets that meet the recommended daily allowances for the mineral improve bone mineral density.

In addition, Dean noted dozens of other studies have linked magnesium to a host of mental health benefits – in treating migraines, tension headaches, insomnia, depression, panic attacks, stress, and anxiety.

She said research has also found that adequate intake of magnesium can help in the prevention and treatment of such conditions as pre-eclampsia, eclampsia, premenstrual syndrome, dysmenorrhea, kidney stones, fibromyalgia, blood clots, fibrositis, tooth decay, insomnia, and muscle and nerve problems.

Are You At Risk?

One of the major problems with magnesium is that current diagnostic tests do not provide an accurate indication of whether a patient has a deficiency. “Doctors don’t have the tools to measure magnesium levels properly,” Dean explains. The best way to tell if you’re getting enough is to consider the long list of symptoms deficiency can cause.

Here are the most common: muscle cramps, twitching, heart palpitations, migraines, angina, irregular heartbeat, asthma, anxiety, fatigue, poor concentration, depression, numbness of hands or feet, back pain, diabetes, high blood pressure, osteoporosis, PMS, and seizures. If you suffer from any of these problems regularly, you may have low levels of magnesium.

Finding the right supplement: However, not all magnesium supplements are the same. The primary side effects of taking the mineral are digestion problems and possible diarrhea. Cheaper supplements have a laxative effect. The solution is to take a quality, time-released supplement that allows your body to absorb the mineral slowly.

Seek out also pesticide free magnesium rich foods in the diet, which include seeds, whole grains, avocados, bananas, dried fruit, figs, artichokes, potatoes and especially leafy green vegetables. Add to these a high quality magnesium supplement, assuring the body of obtaining the level of magnesium it needs for highest function.